2-Phenyl lepidines preparation through microwave assisted Friedel-Crafts alkylation of N-(α-allylbenzyl) anilines supported on silica-sulfuric acid

https://doi.org/10.25100/iyc.v15i1.2621

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Published: Jun 5, 2013
Issue: Vol. 15 No. 1 (2013): Ingeniería y Competitividad
Section Artículos de investigacion

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Authors

Diego A. Roa Universidad Industrial de Santander
Juan Manuel Urbina Juan Manuel Urbina Universidad Industrial de Santander
Abstract

Silica sulfuric acid (SSA) has been efficiently used as solid support in the solvent free microwave assisted synthesis of 2-phenyl lepidines (2-phenyl-4-methylquinolines) from N-(α-allylbenzyl)anilines. Reactions proceed through a two step cascade involving a Friedel-Crafts alkylation + oxidation of the formed 2-phenyltetrahydrolepidines. Good to high reaction yields and short reaction times were observed. Prepared products were identical to the ones already prepared in our lab through a two step synthesis.

How to Cite
1.
Roa DA, Juan Manuel Urbina JMU. 2-Phenyl lepidines preparation through microwave assisted Friedel-Crafts alkylation of N-(α-allylbenzyl) anilines supported on silica-sulfuric acid. inycomp [Internet]. 2013 Jun. 5 [cited 2024 Dec. 22];15(1):71-7. Available from: https://revistaingenieria.univalle.edu.co/index.php/ingenieria_y_competitividad/article/view/2621

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