2-Phenyl lepidines preparation through microwave assisted Friedel-Crafts alkylation of N-(α-allylbenzyl) anilines supported on silica-sulfuric acid
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Silica sulfuric acid (SSA) has been efficiently used as solid support in the solvent free microwave assisted synthesis of 2-phenyl lepidines (2-phenyl-4-methylquinolines) from N-(α-allylbenzyl)anilines. Reactions proceed through a two step cascade involving a Friedel-Crafts alkylation + oxidation of the formed 2-phenyltetrahydrolepidines. Good to high reaction yields and short reaction times were observed. Prepared products were identical to the ones already prepared in our lab through a two step synthesis.
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